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Some polymorphisms in genes related to the immunomodulatory response have been identified (69, 74), such as an increase of TNF-857 TT and CT genotypes (p=0.002), and a significant decrease of IFN gamma low producers (A/A) (P=0.04) in ME/CFS patients in respect to controls (74)

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If the inflammatory response persists, it may lead to chronic inflammation (Fig

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If the stress becomes chronic stress, your adrenal glands can become depleted