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We found that the GCL inhibitor BSO re-sensitized IRE1-null cells to erastin-induced ferroptosis, indicating that GCL is involved in IRE1-regulated GSH synthesis (Supplementary Fig

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Indeed, GAPDH mutants that cannot be oxidized impair the cells ability to generate NADPH following oxidative insult [39]

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Results continue to improve with ongoing treatment as collagen remodeling and tissue regeneration progress

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