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Similarly, the malate-aspartate shuttle (MAS) is deliberated to be the central redox shuttle system shifting, reducing equivalents from the cytosolic NAD + /NADH to the mitochondria that functions in the brain, mainly essential in neuronal cells for the oxidative metabolism of glucose [121]

Curr Top Med Chem 2002;2:113-32

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Numerous toxicity studies have been done to assess the safety of MSM and doses up to 4,845.6 mg per day (4.8 grams) appear to be safe ( However, some people may experience mild reactions if they are sensitive to MSM, such as stomach issues like nausea, bloating and diarrhea

A clinic in a top metropolitan city, like Bangalore, charges significantly higher than a clinic in a non-metropolitan city