tirzepatide cost at cvs Dropping Zepbound: What It Means For Patients, Payers, And Pharma CVS Health chooses Wegovy over

32 One analysis calculated a mean difference favoring tirzepatide by -4.84 kg 60 , while another reported average losses of 9.7 kg for tirzepatide versus 4.81 kg for semaglutide

A stronger product than what we get from a store is dangerous

Unlike CVS Caremark (which removed Zepbound from its standard formulary in July 2025, affecting ~ of Caremark plans), OptumRx is maintaining Zepbound on 2026 formularies for plans that cover obesity medications

In both the phase 2 obesity trial and the MASLD substudy, no specific diet was prescribed and participants received generic lifestyle counseling rather than any carbohydrate-based protocol, yet significant weight loss and substantial liver fat reduction still occurred

Many healthcare providers recommend using a backup barrier method, like condoms, or switching to a non-oral contraceptive like a patch or IUD to ensure continuous protection