Both drugs should be used with caution alongside antidepressants such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), and tricyclic antidepressants (TCAs)
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The term adaptogenic refers specifically to how a substance may affect the bodys response to stress (Healthline, 2024)
But when we look at the literature in patients with PCOS we see an interesting story, serum testosterone seems to decrease when GLP1 inhibitors are taken alone (10) and when they are taken with metformin there is an increase in SHBG (11,12.) This seems to me to again point to how complex the endocrine system is: we dont fully understand the interplay between insulin, sex steroid hormones, and SHBG
A recent highlights the diverse symptoms in a man who underwent stomach surgery