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IshiiTItohKRuizELeakeDSUnokiHYamamotoMet alRole of Nrf2 in the regulation of CD36 and stress protein expression in murine macrophages

The first reported observation that GTPases influence eryptosis was by Attanzio et al., who showed that NSC23766, a specific inhibitor of Rac1 GTPase, was able to ameliorate oxysterol-induced eryptosis [180]

Clinical trial design must account for this heterogeneity, possibly incorporating patient stratification based on imaging, genetic risk factors (e.g., APOE or TREM2 variants), or peripheral cytokine profiles

Clin Biochem 40(34):177180