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We observed knockdown of NRF2 protein and robust growth inhibition upon dox treatment, highlighting the dependency of these cell lines on NRF2 for growth (Fig

Alveolar macrophages derived from circulating monocytes recruited into the lungs by monocyte chemotactic factors produced by lung cells are increased 20-fold in COPD patients and release ROS as superoxide anions and hydrogen peroxide (102)

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In summary, compared with normal cultured cells, the ROS and MDA content of oxidatively damaged cells increased significantly