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Where insulin therapy is required

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IGF-1 operates downstream of growth hormone in the somatomedin axis, which means stacking it with growth hormone secretagogues requires precise timing to avoid receptor desensitization

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Underwood WJ, McGlone JJ, Swanson J, Anderson KA, Anthony R

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This distinction leads to differences in how each compound is evaluated in laboratory environments, particularly in studies examining multi-pathway signaling versus more targeted receptor models

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