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Three things cause most plateaus: metabolic adaptation, dose ceiling, or behavioral drift

(2003) Association between migraine and Celiac disease: results from a preliminary case-control and therapeutic study

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Real-world data from tens of thousands of patients on extended GLP-1 therapy (13+ years) shows that side effects typically plateau after the first 36 months, and many patients report improved quality of life, reduced hunger-related stress, and better disease control if they have type 2 diabetes

That gives it a self-care angle, versus feeling like youre just dribbling water on your face