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Most patients report weight loss within the first four weeks

These individuals may require proactive management strategies and potentially slower titration schedules

[10] Use is contraindicated in individuals with known hypersensitivity to letrozole or any tablet component, in pre-menopausal women when pregnancy remains possible, and during lactation because estrogen depletion may harm fetal development or diminish milk production

The benzyl alcohol in bacteriostatic water also suppresses bacterial growth, which is what allows the reconstituted vial to last 28 days in the fridge instead of 24 hours

In patients with preexisting cardiovascular disease or hyperlipidemia, periodic reassessment is essential to minimize risks of atherosclerosis and cardiac dysfunction