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Reduced motivation, fatigue, and cognitive impairments hinder compliance with necessary diabetes care practices, such as glucose monitoring, dietary adherence, and maintaining physical activity, which may exacerbate hyperglycemia and increases complication risks [127]

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doi: 10.3390/ijms25158021 5

Dosing schedule and titration protocol Semaglutide titration follows a stepped approach designed to minimize gastrointestinal side effects