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Nanoparticles decorated with ligands for cardiomyocyte-specific receptors enable passive targeting (e.g., the EPR effect), active targeting, and intelligent drug release in response to the pathological microenvironment (e.g., pH and enzymes), ensuring drug enrichment and localized release at the cardiac site [255, 256]

doi: 10.1139/cjm-2016-0773, 43 HesseM

M., Barrett, C

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Minimum two to four weeks often required before judging effectiveness for chronic conditions, with some injuries needing six or more weeks to show meaningful response