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10 FDA Regulatory Note: The FDA determined that NAC is excluded from the statutory definition of a 'dietary supplement' under the FD&C Act because it was authorized as an active pharmaceutical ingredient (the antidote for acetaminophen overdose, sold as Mucomyst) before it was widely marketed as a supplement

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This redox reaction triggered by GSH conspicuously reduced the inactivation and efflux of cisplatin and enhanced its chemotherapy toxicity, resulting in considerable inhibition on tumor cells