In a 12-month study of 339 Second Nature members published in JMIR Formative Research, members taking tirzepatide (Mounjaro) lost an average of 22.1% of their body weight, and those taking semaglutide (Wegovy) lost 17.1%, in line with the averages seen in the original clinical trials
Hydroxyethyl starch inhibits glycocalyx-degrading enzymes, facilitating the restoration of glycocalyx thickness and enhancing expression of VE-cadherin, occludin, and zonula occludens-1, reducing albuminfluorescein isothiocyanate infiltration, and improving pulmonary vascular permeability [45]
Side effects are uncommon but may include mild injection-site reactions, flushing, or headache
PMID 27886869
GHKs ability to improve tissue repair has been demonstrated for skin, lung connective tissue, bone tissue, liver, and stomach lining