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Furthermore, butyrate is transported into colonocytes in the gut epithelium via monocarboxylate transporter 1 (MCT1) (Cuff et al., 2002), where it participates in various activities, including stabilization of hypoxia-inducible factor (HIF), inhibition of histone deacetylase (HDAC), and regulation of specific G-protein coupled receptors, which will be discussed later

Its discovery by Sikiri and colleagues opened up a long line of preclinical research into cytoprotection and tissue healing

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doi:10.1128/AAC.00773-07