Ke, Y., Zhang, J., Lv, X., Zeng, X
These phenotypes were not attributed to tamoxifen treatment, as treatment of control mice ( Gclc f/w mice) with tamoxifen failed to cause any weight changes (Fig
(6) There are analyses indicating that more than half of all arthroplasty patients are obese, with one large retrospective cohort of 8.3 million individuals reporting that 64% of primary total knee arthroplasty (TKA) patients and 49% of primary total hip arthroplasty (THA) patients are obese
Rats receiving brainstem-hypothalamic transection do not have a reduction in food intake in response to peripherally administered GLP-1 which suggests that the brainstem plays a critical role in communicating peripheral satiety signals to higher brain centers (Abbott et al., 2005)
Contamination and mislabeling are real, documented problems in the gray-market peptide supply, and they are risks that have nothing to do with the molecules intrinsic pharmacology and everything to do with how the material is made and handled