glp 1 and stomach issues GLP-1 has changed the conversation around weight loss—but it's important to understand what it can cannot do. It's not the right choice for everyone, and it's not a replacement for healthy The Side Effects of GLP-1s

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One of the commonly reported microbiome differences between obese/HFD-fed animals and lean controls is an increased Firmicutes : Bacteroidetes ratio 43,44

Also, the indicated BMI criteria are stricter in Japan as mentioned above, and whether they will be relaxed in the future will be carefully considered

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Take home message Eli Lilly reported on 21 May 2026 that retatrutide produced an average weight loss of up to 30.3% in its Phase 3 TRIUMPH-1 trial, the largest figure reported so far for a weight-loss injection