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Informed consent : Patients must understand the off-label nature of sermorelin use, limited safety data for combination therapy, compounded medication risks, and financial implications

These medications have demonstrated significant weight loss (5-22%) and metabolic benefits in rigorous clinical trials when prescribed and monitored by healthcare providers

However, DON has had difficulty progressing into clinical trials due to concerns regarding its lack of selectivity to GLS and toxicity [110, 113, 114]

Endo M, Yamamoto H, Setsu N, Kohashi K, Takahashi Y, Ishii T, et al

In this consultation, youll discuss your goals, starting weight, comfort with injections, and other factors to determine the best medication for you (as appropriate)