retatrutide type 2 diabetes phase 2 lancet 2023 rosenstock 🚨Breaking: Retatrutide's first 3 T2D data just dropped. ▸ A1C: −2.0% at 40 weeks ▸ Weight: −36.6 lbs (−16.8%) at 12 mg ▸ No weight loss plateau — curve still descending Retatrutide | GLP-1R/GIPR/GCGR ligand |

However, Im now usually first prescribing sporulating probiotics

GLP-1 medications can be expensive, especially for patients without insurance coverage

95% CI, 0.3-5.93), 6 months (HR = 1.79

23andMe has over 11 million people in their research database and used voluntary survey data on medication use, dosage, duration, weight loss, and side effects to match against genetic profiles at scale, making this one of the most powerful datasets anyone has brought to this question

The gap in efficacy between Tirzepatide and Retatrutide, approximately 3-4 percentage points of body weight at comparable doses, is real but smaller than the gap between Semaglutide and Tirzepatide