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Insulin and glucose response: Insulin resistance is a common cause of abdominal weight gain and difficulty losing fat

Samson SL, Vellanki P, Blonde L, Christofides EA, Galindo RJ, Hirsch IB et al (2023) American Association of Clinical Endocrinology Consensus Statement: Comprehensive Type 2 Diabetes Management Algorithm - 2023 Update

L-cell sensitivity to nutrients improves

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Hypothalamic ARC or nodose ganglion (NG) GLP-1Rs are not necessary for the food intake reducing effects of GLP-1R agonists, while the hindbrain DVC is essential for this function ( + neurons in the DVC, including the AP, are predominately (40-65%) responsive to aversive signals (LiCl, cinacalcet)