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Shuo Hu, [email protected] These authors have contributed equally to this work This article was submitted to Biomaterials, a section of the journal Frontiers in Bioengineering and Biotechnology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Clearance: About 0.6 liters/day (faster in people with higher body weight) Half-life: 4.8 days for Datroway, about 5.5 days for DXd This means the drug stays in your body for several days, supporting its dosing every 3 weeks