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Patients on metformin and another antihyperglycemic agent (N=229) and patients not on any antihyperglycemic agents (off therapy for at least 8 weeks, N=41) were randomized after a run-in period of approximately 10 weeks on metformin HCl (at a dose of at least 1500 mg per day) in monotherapy

83,89,90,91,92 Since then, it has also been approved for other indications, such as chronic weight management, under the brand name Saxenda