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There is abundant evidence of higher serum and tissue concentrations of biomarkers for OS and systemic inflammation, as well as decreased concentrations of antioxidants, such as vitamin C and vitamin E in women with preeclampsia [38]

Anything that fails to cross that boundary cannot induce them

In addition to the excellent therapeutic effect on diabetic cardiomyopathy, sinapic acid also ameliorated the expression of apoptosis-related proteins in STZ-induced Wistar rats diabetic kidneys via Nrf2/HO-1 mediated pathways [154]

HIV-1 Tat primes and activates microglial NLRP3 inflammasome-mediated neuroinflammation

This threshold was chosen to prioritize pathways with at least moderate evidence of a link to AD, ensuring that our network was focused on biologically relevant pathways while still being inclusive enough to capture a broad range of potential mechanisms