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However, increased potency requires vigilance

The compound also inhibits inflammatory mediators such as IL-6 and prostaglandins that drive post-inflammatory hyperpigmentation

Similarly, PNPLA3 I148M promotes hepatosteatosis through ABHD5-dependent inhibition of PNPLA2 (75), suggesting that small molecules that target the PNPLA3 I148M/ABHD5 interaction could be potential therapeutics for FLD and diabetes

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