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Perano SJ, Couper JJ, Horowitz M et al (2014) Pancreatic enzyme supplementation improves the incretin hormone response and attenuates postprandial glycemia in adolescents with cystic fibrosis: a randomized crossover trial

They are not signs of treatment failure but reflect the bodys natural adaptation to lower calorie intake and changing metabolic needs

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Covariates Potential confounders were selected based on clinical knowledge

-NADPH (0.8 mM) solution was added after 30 s of incubation, and instantly, the absorbance was read at 405 nm every 30 s for 3 min using a microplate reader (LT-4000, LabTech)