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In addition, mRNA expression of key genes in lysosomes, including acid hydrolases (such as cathepsin A/D), LAMP-1 and LAMP-2, was significantly upregulated following sepsis, hinting that overloaded lysosomal function might be an early marker for poor outcomes for patients with sepsis 22

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85 DNA damage-regulated autophagy modulator 1 (DRAM1) is essential for inducing autophagy and apoptosis and is highly expressed in UC patients