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The Gut-Brain Axis: Interactions between Enteric Microbiota, Central and Enteric Nervous Systems

SAG crosses cell membranes via passive diffusion due to its intrinsically improved lipophilicity

This timing maximises the fat metabolism benefit without disrupting your fast or sleep cycle

Source: Arrone, et al New England J of Medicine May 11, 2025 Researchers randomized about 1,500 people with obesity and without diabetes to be treated with either tirzepatide or semaglutide, both at the highest tolerable recommended doses, and followed them for 72 weeks

Notably, it targets specific adipose tissue areas, making it a prospective solution for localized fat reduction, a phenomenon commonly referred to as spot reduction. This attribute has piqued the interest of both the cosmetic and fitness industries, where targeted fat loss is a desirable outcome