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The brain is remarkably sensitive to peptide signaling, which is why fatigue can be such a prominent early effect of GLP-1 agonist therapy

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Oxidative Stress and Redox Regulation

Otherwise, intra-abdominal hypertension adversely affects many organs, such as the brain, heart, lungs, kidneys, and gastrointestinal tract ( Furthermore, as an immediate effect, the abdominal, thoracic, and cranial cavities interact with each other (Malbrain and Wilmer, 2007

The psychology of the peptide space is also worth noting, as it ties into how wellness and body optimization can be gendered