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More GLP-1 was needed to have the same biological effect, meaning they were resistant to GLP-1." This switch around was so unexpected, the researchers ran further tests on mouse models with the PAM gene deactivated

Safety and efficacy of glucagon-like peptide-1 (GLP-1) receptor agonists in patients with weight regain or insufficient weight loss after metabolic bariatric surgery: A systematic review and meta-analysis