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Arg3 Substitution: Prevents binding to IGFBPs, keeping the peptide "free" and bioactive

Its effect is assessed as being comparable to bariatric metabolic surgery, which alters the structure of the stomach and small intestine to limit food intake and absorption

It is worth noting that the active ingredient semaglutide is a synthetic peptide, and the formulation also contains excipients including disodium phosphate dihydrate, propylene glycol, and phenol, as listed in the current SmPC

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2025;48(1 Suppl 1):S181206