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Advanced paternal age is associated with a decline in function of the male reproductive system, sperm quality, and fertility owing to age-associated accumulation of DNA damage and mutations or age-associated germ cell loss, which is further correlated with paternal contribution to chromosomal damage and genetic health problems in the children

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Didangelos T, Karlafti E, Kotzakioulafi E, et al

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Applied Microbiology and Biotechnology, 68 (4), 445455