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Journal of Physiology (Paris), 91(3), 173178

Finally, this unique phenotype offers mechanistic insights: the dissociation between severe adiposity and a favorable cardiometabolic profile suggests that MC4R signaling plays a non-redundant role in integrating energy balance with cardiovascular regulation [2,32,33]

This block could also be caused by the decreased abundance of acetyl-CoA (Figure 5), which is a critical reagent for the synthesis of citrate by citrate synthase

Marraccini P

This localization theoretically reduces systemic side effects and cancer concerns compared to long-acting analogs, though local effects may still influence surrounding tissues