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[Article] [PubMed]52

Insulin prevents depolarization of the mitochondrial inner membrane in sensory neurons of type 1 diabetic rats in the presence of sustained hyperglycemia

long after the meds are done

while some patients report subtle shifts in energy within a few weeks, it typically takes 2 to 3 months of daily supplementation to sufficiently replenish deep intracellular nutrient deficits and observe meaningful changes in baseline fatigue