Coniferyl ferulate is a potent inhibitor of glutathione S-transferase ( GST ) ( IC = 0.3 M), which downregulates 50 P-gp expression, induces apoptosis in B-MD-C1 (ADR+/+) cells, and reverses multidrug resistance
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Aug;124:10617
Short-term safety is well-established at doses up to 1200mg per day, but chronic daily supplementation may downregulate endogenous glutathione synthesis through negative feedback on gamma-glutamylcysteine synthetase
