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Brain insulin resistance is an important pathogenetic feature of AD and is mediated primarily by impaired insulin signaling (Sdzikowska and Szablewski, 2021)

The also enhance microvascular perfusion through the activation of PKA-NO and PI3K-Akt-eNOS pathways, promoting the delivery of oxygen and nutrients

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There may be bias due to confounding in our study, however, this is the largest study to date that evaluates the harm with transfusions in the setting of a variceal bleed

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