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If youve been reading this newsletter, you know Ive written about the fact that OA patients on GLP-1 drugs report pain improvement long before any meaningful weight loss occurs

Short answer, the one that matters: no meaningful human signal, the thyroid black box is a rodent-dose precaution (the same way the old estrogen black box was more politics than data), and we actually see lower rates of some cancers in people taking them

2007 Oct;125(10):1396-401

Say goodbye to stubborn blemishes and hello to a radiant complexion thats perfect for answering the joys of childhood

This also lowers antioxidants and increases oxidative stress, which harms the nerves energy system (the mitochondria)