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In a rat model of IBS, intraperitoneal administration of exendin-4 normalized stress-induced defecation and visceral pain sensitivity by modulating enteric neuronal function through GLP-1 receptors in submucosal and myenteric ganglion neurons [52]

This evidence makes gabapentin potentially helpful for different types of anxiety disorders

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Thioacetamide is used as an appropriate model in the studies of anti poisoning as well as protective effects of medicines and different compounds on liver [11]