And we know that also now, we have really good actually clinical studies that show that there is a change in food choice and people can control their food intake better
Because strong bones matter just as much as a lower number on the scale.
Patients typically observe: Diminished hunger signals and cravings for calorie-rich foods Heightened meal satisfaction with less food intake Effective portion control, enabling consistent weight management Stable, sustainable weight loss without the recurrence associated with rapid loss Enhancements in metabolic health, including improved blood sugar, cholesterol, and blood pressure levels The initial phase often sees notable appetite reduction within weeks, evolving into meaningful weight reduction as treatment progresses
Vignaud C, Rakotozafy L, Falguieres A, Potus J, Nicolas J
Notably, loss of function GPX4 was the top hit that enhances sensitivity to giredestrant, in line with the palbociclib screen