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(Source 1) Suboptimal and deficient glutathione levels are associated with aging and an increased risk for chronic diseases, including: Mitochondrial dysfunction Neurodegenerative disease, including Alzheimers and Parkinsons disease Cancer Chronic liver disease Metabolic disease, including diabetes and hypertension Cardiovascular disease Pulmonary Infertility Autoimmune diseases, including lupus and multiple sclerosis Mental health disorders Cystic fibrosis (Source 1, 2) A viral illness, including SARS-CoV-2, the virus that causes Covid-19, can also cause glutathione deficiency

& Guzman, M., 1997

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Ethics declarations Competing interests D.H., C.M.R., L.J., J.F., and J.G

In preclinical studies, NTZ suppresses intracellular M.tb proliferation by inhibiting the enzymatic activity of human quinone oxidoreductase (NQO1), which in turn inhibits the mTORC1 pathway and induces autophagy [19]