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Acknowledgements This study was approved by the Alfred Hospital Ethics Committee (project number 463/18) and the Australian Institute of Health and Welfare Ethics Committee (EO2018/5/501)

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

Experimental studies have shown that metformin treatment can improve cognitive performance in female mice with APP transgenic models (180)

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If possible, check the internal temperature with a thermometer or use the coldest setting available