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APRNs can identify and diagnose MDD by taking a complete health history, listening to patients concerns, having patients complete the PHQ-9 questionnaire, and communicating any concerns to other health care professionals (9)

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**Who should consider it:** Patients who have plateaued on Semaglutide or Tirzepatide, those seeking the highest available efficacy, early adopters comfortable with a medication still in trials, and always under close medical supervision