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RR for Alzheimer disease, 0.62 [95% CI, 0.32-1.22
Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent
Use: Intended solely for laboratory research
By slowing digestion and increasing satiety, patients feel full longer and avoid spikes and crashes in energy
Some committee members said that they worried about the implications of the FDA allowing itself to skip over clinical trials when permitting pharmacies to dispense medications
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