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To help put it into perspective, consider this factoid: For women between ages 50 and 59, estrogen-only HRT poses a smaller breast cancer risk than drinking two glasses of wine per night, and combination HRT has an equivalent risk, according to Joanne Weidhaas, MD, PhD, a professor of radiation oncology at the David Geffen School of Medicine at UCLA and co-discoverer of the KRAS -variant, an inherited genetic variant associated with an increased risk of breast, ovarian, and other cancers