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Previously it has been reported that curcumin as an anti-oxidant reduce gene and protein expression of KIM-1 and NGAL and alleviate oxidative toxic stress in the kidney tissue of type 1 diabetes rats [17]

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It also downregulates ROS generation and Nrf2 expression induced by cyclic mechanical stress in periodontal ligament stem cells (PDLSCs) ( 2.5 Inflammation- and oxidative stressassociated biomarkers and therapeutic strategies in osteoporosis Recent clinical studies have identified several circulating biomarkers and imaging indicators associated with oxidative stress and inflammation-mediated bone loss

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