It has shown that ISL as a potent agonist of SIRT1-AMPK signaling in ethanol exposure-induced steatosis following prevent ethanol-induced lipid accumulation through not increasing fatty acid oxidation but blocking lipid synthesis (Na et al., 2018)
doi: 10.1681/ASN.V12122747
Peritoneal B1 cells are metabolically distinct from splenic FoB cells, relying on high levels of TCA, glycolysis and oxPPP to sustain homeostatic self-renewal at least in part through significant lipid metabolism 141
Validation should cover sensitivity, accuracy, recovery, carryover, and precision across the expected concentration range (Thiel et al., 2023)
But what is important is that acid ceramidase is targetable, and other labs have already gotten that work startedlater on, we can hopefully build on what they learn. The more we learn about ferroptosis, adds Maher, the more possibilities there are for healthy aging innovations