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In parallel, synthetic biology approaches explore LR3 analogs with modified IGF-1R affinity, increased selectivity versus the insulin receptor, or biased activation of specific signaling pathways (pMAPK versus pAkt) to dissociate proliferative from metabolic effects

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These assays confirmed the plant's strong antioxidant activity, which was attributed to the high concentrations of phenolic and flavonoid compounds present in the extracts