Second, older adults, who represent a significant proportion of GLP-1 users, have reduced physiological reserve and are more vulnerable to electrolyte disturbances
Although liraglutide controlled type 2 diabetes and led to weight loss, early trials found that the drug gave rise to unacceptable side-effects, such as nausea
For over a decade, the consensus was that animal models could not deliver useful treatments for mental disorders, and that peptides were the wrong class of molecule for brain disease
As the list of potential benefits of GLP-1 grows, Drucker warns that the buzz must be balanced with caution and scientific rigour
Almassi GH, Wagner TH, Carr B, Hattler B, Collins JF, Quin JA, et al