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Energy Balance and Fat Metabolism GIP and glucagon receptors play roles in: Fat utilisation Energy expenditure Metabolic flexibility By influencing both calorie intake and calorie expenditure, retatrutide is being studied as a compound that may address weight management more comprehensively than appetite suppression alone

Metabolism Open , 22 , 100283

2 Neurological and behavioral models Because GLP-1R agonists cross the blood-brain barrier to influence appetite via hypothalamic signaling and reward pathways, researchers are increasingly interested in how these peptides affect preclinical models related to the central nervous system