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GLP-1s may additionally impact other physiological changes observed in the perimenopausal period, including vasomotor symptoms like hot flashes and night sweats, declines in bone health, and unhealthy changes in body composition (gains in fat mass and declines in muscle mass), but whether these impacts are beneficial or harmful for women's health remains unknown

Good clinical practice dictates a patient- specific plan to taper the dose of the opioid gradually

Thyroid monitoring: GLP-1 receptor agonists carry a class-wide boxed warning regarding medullary thyroid carcinoma (MTC) risk, based on findings in rodent studies

It can be administered intramuscularly at a 90-degree angle or intravenously by a licensed professional

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