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They were treated with vehicle, Tamoxifen (30 mg/kg, oral gavage), or a combination of Tamoxifen and Sorafenib (30 mg/kg, oral gavage)

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As mitochondria are a major target of APAP hepatotoxicity, mitochondrial quality control and clearance of dysfunctional mitochondria through mitophagy, emerges as an important strategy to limit oxidative stress and the engagement of molecular events leading to cell death